Abstract

Sexual dysfunction and insomnia are common side effects of prostate cancer (PCa) treatment, but the link between these symptoms has not been explored. We explore here the association between various sexual parameters and insomnia symptoms in PCa patients. Data were collected via an online survey with recruitment through various PCa organizations. One hundred and forty two patients (age = 67.3 ± 8.9 years) completed the survey. The majority were in a relationship (84.6%), of Caucasian ethnicity (83.1%), and 33% had previously received androgen deprivation therapy (ADT). Control variables—age, number of comorbidities, past ADT use, body mass index, depression, anxiety, fatigue and daytime sleepiness—explained 58.2% of the variance for insomnia symptoms. Including orgasm difficulty in the models accounted for an additional 2.1% in the variance in insomnia symptoms. Conversely, the control variables listed above together with insomnia symptoms predicted 37.7% of the overall variance in orgasm difficulty in PCa patients. These data suggest that sexual rehabilitation programs for PCa patients should assess insomnia symptoms, and therapies to improve sexual function or sleep quality may be beneficial in both functions given the relationship between sleep and orgasm functions in this population.

摘要

性功能障碍和失眠是前列腺癌 (PCa) 治疗的常见副作用，但尚未探索这些症状之间的联系。我们在这里探讨了 PCa 患者各种性参数与失眠症状之间的关联。数据是通过在线调查收集的，并通过各种 PCa 组织进行招聘。142 名患者（年龄 = 67.3 ± 8.9 岁）完成了调查。大多数人有关系 (84.6%)，白人种族 (83.1%)，33% 以前接受过雄激素剥夺疗法 (ADT)。控制变量——年龄、合并症数量、过去 ADT 使用情况、体重指数、抑郁、焦虑、疲劳和白天嗜睡——解释了 58.2% 的失眠症状方差。在模型中包括高潮难度占了额外的 2。失眠症状的方差为 1%。相反，上面列出的控制变量与失眠症状一起预测了 PCa 患者性高潮难度总体方差的 37.7%。这些数据表明，PCa 患者的性康复计划应该评估失眠症状，鉴于该人群的睡眠和性高潮功能之间的关系，改善性功能或睡眠质量的疗法可能对这两种功能都有益。