This study aimed to identify and analyze the characteristics of highly cited articles in phosphoinositide 3-kinase (PI3K) research using the Science Citation Index Expanded from 1900 to 2016. Altogether 1,922 highly cited papers in seven document types with cited at least 100 times since publication to the end of 2016 from Web of Science Core Collection were found, and a total of 1,556 highly cited articles were published from 1990 to 2014. The articles were analysed in terms of document type, language of publication, trends in publication, journals, Web of Science categories, and publications of countries, institutions, and authors. The results showed that Journal of Biological Chemistry led 211 journals. The top three categories were biochemistry and molecular biology, cell biology, and oncology. The USA took the lead position among 43 countries with 67% of all the highly cited articles, and Harvard University of the USA with 14% of all highly cited articles was the most productive institution. A comprehensive analysis of keywords revealed that activation, pathway, Akt, and apoptosis were recent foci. In addition, classic articles with more than 1,000 citations since publication to the end of 2016 are also discussed.

中文翻译：

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高被引磷酸肌醇 3-激酶 (PI3K) 研究论文的文献计量分析

本研究旨在利用从 1900 年到 2016 年扩展的科学引文索引来识别和分析磷酸肌醇 3-激酶 (PI3K) 研究中高被引论文的特征。 自发表以来被引用至少 100 次的七种文献类型共 1,922 篇高引用论文到 2016 年底从 Web of Science 核心合集中找到，1990 年至 2014 年共发表高被引论文 1,556 篇。从文献类型、发表语言、发表趋势、期刊、Web科学类别，以及国家、机构和作者的出版物。结果显示Journal of Biological Chemistry领先211个期刊。排名前三的类别是生物化学和分子生物学、细胞生物学和肿瘤学。美国以 67% 的高被引论文数在 43 个国家中名列前茅，美国哈佛大学以 14% 的高被引论文数位居榜首。对关键词的综合分析表明，激活、通路、Akt 和细胞凋亡是最近的焦点。此外，还讨论了自出版至 2016 年底引用超过 1000 次的经典文章。