An efficient synthetic strategy for the synthesis of 6-amino-1-(((2-chloroquinolin-3-yl)methylene)amino)-2-oxo-4-(aryl)-1,2-dihydropyridine-3,5-dicarbonitriles is well described in this paper. Structures of synthesized compounds have been identified by standard spectroscopic techniques like ¹H NMR, ¹³C NMR, IR and mass spectroscopy. Results of the biological activity reveals that electron withdrawing groups and presence of –OH group on meta position play a significant role for the increment in the antibacterial and antifungal activities respectively of 3a-j. In the present study, it has been observed that compounds 3i and 3e are the most active antimicrobials.

中文翻译：

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2-吡啶酮喹啉杂化物作为有效的抗菌和抗真菌剂

一种合成6-氨基-1-（（（（2-氯喹啉-3-基）亚甲基）氨基）-2-氧代-4-（芳基）-1,2-二氢吡啶-3,5-的有效合成策略本文对二碳腈进行了很好的描述。合成化合物的结构已通过标准光谱技术鉴定，例如¹ H NMR，¹³ C NMR，IR和质谱。生物活性的结果表明，吸电子基团和-OH基在间位上的存在分别对3a-j的抗菌和抗真菌活性的增加起重要作用。在本研究中，已经观察到化合物3i和3e是活性最高的抗菌剂。