Sensory perception and emotional disorders are disproportionally represented in men and women and are thus thought to be modulated by different sex hormones in various conditions. Among the most important hormones perceived to affect sensory processing and transduction is estrogen. Numerous previous researchers have endeavored to demonstrate that estrogen is capable of modulating the activity of sensory neurons in peripheral and central sites in female, male, or castrated animals. However, the underlying mechanisms of its modulation of neuronal activity are somewhat unclear. In the present review, we discuss the possible cellular and molecular mechanisms involved in the modulation of nociception by estrogen.

中文翻译：

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疼痛调节中的雌激素受体：细胞信号

感官知觉和情绪障碍在男性和女性中不成比例地表现出来，因此被认为是在各种情况下由不同的性激素调节的。被认为影响感觉处理和转导的最重要的激素是雌激素。许多先前的研究人员已经努力证明雌激素能够调节雌性、雄性或去势动物的外周和中枢部位的感觉神经元的活动。然而，其调节神经元活动的潜在机制尚不清楚。在本综述中，我们讨论了雌激素对伤害感受的调节所涉及的可能的细胞和分子机制。