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Herbal Drugs and Natural Products in the light of Nanotechnology and Nanomedicine for Developing Drug Formulations
Mini-Reviews in Medicinal Chemistry ( IF 3.8 ) Pub Date : 2021-01-31 , DOI: 10.2174/1389557520666200916143240
Hiwa M. Ahmed 1 , Seyed Nabavi 2 , Sahar Behzad 3
Affiliation  

Natural products and medicinal plants have played a vital role in providing healthcare and ensuring well-being for many civilizations since antiquity. It is estimated that around 50% of drugs in the market have a natural product origin especially medicinal plants and herbal drugs, animals, fungi, and marine organisms. Some of these biologically active constituents of extracts have low absorption and distribution which, as a result, lead to loss of bioavailability and efficacy and might hamper their applications in the clinic. To overcome these impediments for the formulation of herbal drugs, food supplements, and essential oils, several nanomedical approaches such as liposomes, microemulsions, polymeric nanoparticles, solid lipid nanoparticles (SLNs), liquid crystal systems (LC), and precursor systems for liquid crystals (PSLCs) have been proposed. Nanoparticles have been used to modify and ameliorate the pharmacokinetic and pharmacodynamic properties of different drugs, thus incorporating biotechnological systems may be useful to enhance the bioavailability and bioactivity of herbal drug formulations. Consequently, essential for any natural compounds is the extent of its absorption after being ingested and its ability to be distributed in various tissues or organs of the body. The present review article aims to give an overview of the recent advancements in developing herbal drug formulations based on nanoparticle technologies.



中文翻译:

从纳米技术和纳米药物角度看草药和天然产物开发药物配方

自古以来,天然产品和药用植物在提供医疗保健和确保许多文明的福祉方面发挥了至关重要的作用。据估计,市场上约有50%的药物来自天然产品,特别是药用植物和草药,动物,真菌和海洋生物。提取物中的某些生物活性成分吸收和分布低,结果导致生物利用度和功效下降,并可能妨碍其在临床中的应用。为了克服用于草药,食品补充剂和精油配制的这些障碍,几种纳米医学方法,例如脂质体,微乳剂,聚合物纳米颗粒,固体脂质纳米颗粒(SLN),液晶系统(LC)和液晶前体系统(PSLC)已被提出。纳米颗粒已被用于修饰和改善不同药物的药代动力学和药效学性质,因此并入生物技术系统可能对增强草药制剂的生物利用度和生物活性有用。因此,对于任何天然化合物而言,必不可少的是其被摄入后的吸收程度以及其在人体各种组织或器官中分布的能力。本文的目的是概述基于纳米技术开发草药制剂的最新进展。因此,对于任何天然化合物而言,必不可少的是其被摄入后的吸收程度以及其在人体各种组织或器官中分布的能力。本文的目的是概述基于纳米技术开发草药制剂的最新进展。因此,对于任何天然化合物而言,必不可少的是其被摄入后的吸收程度以及其在人体各种组织或器官中分布的能力。本文的目的是概述基于纳米技术开发草药制剂的最新进展。

更新日期:2021-02-11
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