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Advancement in Pharmacological Activities of Benzothiazole and its Derivatives: An Up to Date Review
Mini-Reviews in Medicinal Chemistry ( IF 3.8 ) Pub Date : 2021-01-31 , DOI: 10.2174/1389557520666200820133252
Sumit 1 , Arvind Kumar 1 , Arun Kumar Mishra 1
Affiliation  

Benzothiazole is a heterocyclic aromatic and bicyclic compound in which, benzene ring is attached with thiazole ring. This nucleus is established in marine as well as terrestrial natural compounds. The benzothiazole skeleton is established in a broad variety of bioactive heterocycles and natural products. The benzothiazole nucleus is considered as the principle moiety in several biologically active compounds. Over the decade, chemists are paying more attention towards the revision of the biological and therapeutic activities such as antimicrobial, analgesic, antiinflammatory, antitubercular, antiviral and antioxidant of benzothiazole containing compounds. The molecular structures of a number of potent drugs including Frentizole, Pramipexole, Thioflavin T and Riluzole etc., are based on benzothiazole skeleton. The present work is the compilation and presentation of all available information in a systematic manner with an aim to present the findings in a way, which may be beneficial for future research.



中文翻译:

苯并噻唑及其衍生物的药理活性研究进展:最新评论

苯并噻唑是杂环芳族和双环化合物,其中苯环与噻唑环相连。这个核在海洋以及陆地天然化合物中都建立了。苯并噻唑骨架存在于多种生物活性杂环和天然产物中。苯并噻唑核被认为是几种生物活性化合物的主要组成部分。在过去的十年中,化学家更加关注生物学和治疗活性的修订,例如含苯并噻唑的化合物的抗菌,止痛,抗炎,抗结核,抗病毒和抗氧化剂。包括苯达唑,普拉克索,硫黄素T和利鲁唑等在内的许多有效药物的分子结构均基于苯并噻唑骨架。

更新日期:2021-02-11
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