Cancer cells are known to significantly alter their lipid profiles in response to changes in extracellular lipid availability. Recent studies have shown that in response to lipid deprivation, cancer cells display significant changes in their cellular lipid homeostasis. These changes have been linked to the modulation of de novo lipid synthesis pathways that are markedly altered under lipid‐deprived growth conditions. However, the effects of such environment on intracellular lipid trafficking—that could also affect cellular lipid homeostasis—have not been widely investigated. The presented work studies the effect of lipid deprivation on expression of genes for lipid transport proteins (LTPs) in cancer cell lines.

中文翻译：

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脂质运输相关基因在脂质剥夺癌细胞中的表达

已知癌细胞响应于细胞外脂质利用率的变化而显着改变其脂质谱。最近的研究表明，响应脂质剥夺，癌细胞在细胞脂质稳态中显示出显着变化。这些变化与从头脂质合成途径的调节有关，这些途径在脂质剥夺的生长条件下显着改变。但是，这种环境对细胞内脂质运输的影响（也可能影响细胞脂质稳态）尚未得到广泛研究。提出的工作研究了脂质剥夺对癌细胞系中脂质转运蛋白（LTP）基因表达的影响。