Abstract

Hydrogels—natural or synthetic polymer networks that swell in water—can be made mechanically, chemically and electrically compatible with living tissues. There has been intense research and development of hydrogels for medical applications since the invention of hydrogel contact lenses in 1960. More recently, functional hydrogel coatings with controlled thickness and tough adhesion have been achieved on various substrates. Hydrogel-coated substrates combine the advantages of hydrogels, such as lubricity, biocompatibility and anti-biofouling properties, with the advantages of substrates, such as stiffness, toughness and strength. In this review, we focus on three aspects of functional hydrogel coatings: (i) applications and functions enabled by hydrogel coatings, (ii) methods of coating various substrates with different functional hydrogels with tough adhesion, and (iii) tests to evaluate the adhesion between functional hydrogel coatings and substrates. Conclusions and outlook are given at the end of this review.

中文翻译：

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功能性水凝胶涂料

摘要

水凝胶——在水中膨胀的天然或合成聚合物网络——可以在机械、化学和电学上与活组织相容。自 1960 年发明水凝胶隐形眼镜以来，一直在大力研究和开发用于医疗应用的水凝胶。最近，已在各种基材上实现了具有可控厚度和坚韧附着力的功能性水凝胶涂层。水凝胶涂层基材结合了水凝胶的优点，如润滑性、生物相容性和抗生物污垢性能，以及基材的优点，如刚度、韧性和强度。在这篇综述中，我们关注功能性水凝胶涂层的三个方面：（i）水凝胶涂层的应用和功能，(ii) 用具有坚韧附着力的不同功能水凝胶涂覆各种基材的方法，以及 (iii) 评估功能水凝胶涂层与基材之间附着力的测试。本综述的结尾给出了结论和展望。