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Energetics of mesoscale cell turbulence in two-dimensional monolayers
Communications Physics ( IF 5.5 ) Pub Date : 2021-02-10 , DOI: 10.1038/s42005-021-00530-6
Shao-Zhen Lin , Wu-Yang Zhang , Dapeng Bi , Bo Li , Xi-Qiao Feng

Investigation of energy mechanisms at the collective cell scale is a challenge for understanding various biological processes, such as embryonic development and tumor metastasis. Here we investigate the energetics of self-sustained mesoscale turbulence in confluent two-dimensional (2D) cell monolayers. We find that the kinetic energy and enstrophy of collective cell flows in both epithelial and non-epithelial cell monolayers collapse to a family of probability density functions, which follow the q-Gaussian distribution rather than the Maxwell–Boltzmann distribution. The enstrophy scales linearly with the kinetic energy as the monolayer matures. The energy spectra exhibit a power-decaying law at large wavenumbers, with a scaling exponent markedly different from that in the classical 2D Kolmogorov–Kraichnan turbulence. These energetic features are demonstrated to be common for all cell types on various substrates with a wide range of stiffness. This study provides unique clues to understand active natures of cell population and tissues.



中文翻译:

二维单层中尺度细胞湍流的能量学

集体细胞规模的能量机制研究对于理解各种生物学过程(例如胚胎发育和肿瘤转移)是一个挑战。在这里,我们研究了汇合的二维(2D)细胞单层中自我维持的中尺度湍流的能量学。我们发现上皮细胞层和非上皮细胞单层中的集体细胞流的动能和内吞塌陷为概率密度函数族,其遵循q-高斯分布而不是麦克斯韦-玻尔兹曼分布。随着单层的成熟,涡旋涡与动能成线性比例。能谱在大波数时表现出功率衰减规律,其标度指数与经典的二维Kolmogorov–Kraichnan湍流的标度指数明显不同。这些精力充沛的功能已被证明是具有各种硬度的各种基材上所有细胞类型所共有的。这项研究提供了独特的线索来了解细胞群体和组织的活跃性质。

更新日期:2021-02-10
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