In this study, a novel and simple fluorescent carbon quantum dots (CQDs) based nano-sensor for colchicine determination has been prepared. The nitrogen doped CQDs probe was prepared using uric acid as a carbon/nitrogen source via a one-step pyrolysis. The sensor is based on inner filter effect (IFE) where colchicine acts as a powerful absorber that affects the excitation of the fluorescer (CQDs). This overlap results in a quantitative attenuation of the fluorescence of CQDs with increasing colchicine concentration in the range of 2–25 μM. The developed sensor has the advantages of simplicity, less time-consuming, convenience and satisfactory selectivity for colchicine determination in pharmaceutical dosage forms.

在这项研究中，基于秋水仙碱测定的新型和简单的荧光碳量子点（CQDs）为基础的纳米传感器已准备就绪。使用尿酸作为碳/氮源通过一步热解制备了氮掺杂的CQDs探针。该传感器基于内部过滤器效应（IFE），秋水仙碱可作为强大的吸收剂，影响荧光剂（CQD）的激发。重叠导致秋水仙碱浓度在2–25μM范围内，CQD的荧光定量衰减。所开发的传感器具有简单，耗时少，方便和在药物剂型中秋水仙碱测定中具有令人满意的选择性的优点。