Pongamia pinnata (Fabaceae) is among those categories of plants mentioned in Ayurveda and traditionally known to use in several types of disease and disorders. The objective of the present work was to investigate the anti-psoriatic activity of Pongamia pinnata leaves extracts in Herbal gel formulation. Hydroalcoholic leaves extract of Pongamia pinnata was first subjected to phytochemical screening and quantification of phytoconstituents. Herbal gel was prepared containing Pongamia pinnata extracts using Carbopol 934 as gelling agent. The prepared gel formulations were studied for pH, viscosity, Spreadability and in vitro diffusion studies. The imiquimod-induced psoriatic mouse model, showed a prominent anti-psoriatic activity of the extract as evident through index grading. Treatment with extract confirmed a noteworthy reduction in psoriasis in the treated groups as there was a considerable diminution in the thickness and scaling of skin. Lack of proper treatment and disadvantages associated with allopathic medicines pave the way to extensive research in natural products with anti-psoriatic activity. The present research scientifically justified the anti-psoriatic activity of the Hydroalcoholic extracts of Pongamia pinnata leaves.

中文翻译：

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含樟子松提取物的凝胶对咪喹莫特诱发的牛皮癣的抗银屑病活性评估

Pongamia pinnata（Fabaceae）是阿育吠陀中提到的植物种类之一，传统上已知可用于几种类型的疾病和病症。本工作的目的是研究草药凝胶制剂中的樟子松叶子提取物的抗银屑病活性。首先对Pongamia pinnata的水醇叶片提取物进行植物化学筛选和植物成分的定量分析。使用Carbopol 934作为胶凝剂，制备了含有Pongamia pinnata提取物的草药凝胶。研究了制备的凝胶制剂的pH，粘度，可扩展性和体外扩散研究。咪喹莫特诱导的银屑病小鼠模型表现出提取物的突出的抗银屑病活性，这通过指数分级可见一斑。用提取物治疗证实了在治疗组中牛皮癣的显着减少，因为皮肤的厚度和鳞屑明显减少了。与同种疗法药物有关的缺乏适当治疗和缺点为在具有抗银屑病活性的天然产品中进行广泛研究铺平了道路。本研究科学证明了Pongamia pinnata叶片的水醇提取物的抗银屑病活性。