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Epigenetic regulation of retinal development
Epigenetics & Chromatin ( IF 3.9 ) Pub Date : 2021-02-09 , DOI: 10.1186/s13072-021-00384-w
Reza Raeisossadati 1, 2 , Merari F R Ferrari 1 , Alexandre Hiroaki Kihara 3 , Issam AlDiri 2 , Jeffrey M Gross 2
Affiliation  

In the developing vertebrate retina, retinal progenitor cells (RPCs) proliferate and give rise to terminally differentiated neurons with exquisite spatio-temporal precision. Lineage commitment, fate determination and terminal differentiation are controlled by intricate crosstalk between the genome and epigenome. Indeed, epigenetic regulation plays pivotal roles in numerous cell fate specification and differentiation events in the retina. Moreover, aberrant chromatin structure can contribute to developmental disorders and retinal pathologies. In this review, we highlight recent advances in our understanding of epigenetic regulation in the retina. We also provide insight into several aspects of epigenetic-related regulation that should be investigated in future studies of retinal development and disease. Importantly, focusing on these mechanisms could contribute to the development of novel treatment strategies targeting a variety of retinal disorders.

中文翻译:

视网膜发育的表观遗传调控

在发育中的脊椎动物视网膜中,视网膜祖细胞 (RPC) 增殖并产生具有精细时空精度的终末分化神经元。谱系定型、命运决定和终末分化受基因组和表观基因组之间复杂的串扰控制。事实上,表观遗传调控在视网膜中的许多细胞命运规范和分化事件中起着关键作用。此外,异常的染色质结构会导致发育障碍和视网膜病变。在这篇综述中,我们强调了我们对视网膜表观遗传调控理解的最新进展。我们还提供了对表观遗传相关调控的几个方面的见解,这些方面应该在未来的视网膜发育和疾病研究中进行调查。重要的,
更新日期:2021-02-09
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