The current review discusses the different synthetic pathways for one of the most important and interesting heterocyclic ring systems, 1,4-dihydropyridine. This cyclic system depicts diverse pharmacological action on several receptors, channels, and enzymes. Dihydropyridine moiety plays an important role in several calcium-channel blockers. Moreover, it has been exploited for the treatment of a variety of cardiovascular diseases due to its potential antihypertensive, anti-angina, vasodilator, and cardiac depressant activities. Furthermore, it also shows antibacterial, anticancer, anti-leishmanial, anticoagulant, anticonvulsant, anti-tubercular, antioxidant, antiulcer, and neuroprotective properties. Several reports have demonstrated dihydropyridine derivatives as a potentiator of cystic fibrosis transmembrane conductance regulator protein, potent antimalarial agent and HIV-1 protease inhibitor. Herein, we have briefly reviewed different novel chemistry and the synthesis of 1,4-dihydropyridine.

目前的审查讨论了最重要和最有趣的杂环系统之一，1，4-二氢吡啶的不同合成途径。该循环系统描述了对几种受体，通道和酶的多种药理作用。二氢吡啶部分在几种钙通道阻滞剂中起重要作用。此外，由于其潜在的抗高血压，抗心绞痛，血管扩张剂和心脏抑制活性，已被用于治疗多种心血管疾病。此外，它还显示出抗菌，抗癌，抗利什曼肽，抗凝血，抗惊厥，抗结核，抗氧化剂，抗溃疡和神经保护特性。一些报道表明二氢吡啶衍生物可作为囊性纤维化跨膜电导调节蛋白的增强剂，强效抗疟药和HIV-1蛋白酶抑制剂。在这里，我们简要回顾了不同的新型化学和1,4-二氢吡啶的合成。