In recent decades, much attention has been given to cyclopropyl scaffolds, which commonly exist in natural products and synthetic organic molecules. Clinical drug molecules with cyclopropyl rings are an area of focus in therapeutic research due to their interesting chemical properties and unique pharmacology activity. These molecular drugs against different targets are applicable in some therapeutic treatment fields including cancer, infection, respiratory disorder, cardiovascular and cerebrovascular diseases, dysphrenia, nervous system disorders, endocrine and metabolic disorders, skin disease, digestive disorders, urogenital diseases, otolaryngological and dental diseases, and eye diseases. This review is a guide for pharmacologists who are in search of valid preclinical/clinical drug compounds where the progress, from 1961 to the present day, of approved marketed drugs containing cyclopropyl scaffold is examined.

近几十年来，人们对环丙基支架给予了极大的关注，环丙基支架通常存在于天然产物和合成有机分子中。具有环丙基环的临床药物分子由于其有趣的化学性质和独特的药理活性而成为治疗研究的重点领域。这些针对不同目标的分子药物可用于某些治疗领域，包括癌症，感染，呼吸系统疾病，心血管和脑血管疾病，精神障碍，神经系统疾病，内分泌和代谢疾病，皮肤病，消化系统疾病，泌尿生殖系统疾病，耳鼻喉科和牙科疾病和眼疾。这篇评论为正在寻找有效的临床前/临床药物化合物的药理学家提供指南，从1961年至今，