Quinazoline and/or chalcones derivatives are important targets in several areas of chemical sciences, mainly, in the medicinal chemistry and pharmaceutical research. The purpose of this review was to systematize the information available in the literature, including patents, regarding the benefits, exerted by the combination of these two pharmacophores into single molecules. These hybrid compounds can exhibit different biological activities, causing a synergistic or a new effect, compared to the individuals. The variability of biological activities includes anticancer, anti-Alzheimer, antiviral and antimicrobial activities, among others. Additionally, synthetic methodologies to prepare the different molecular architectures were discussed based on their similarities. The increasing number of publications indicates the importance of molecular hybridization in the field of drug discovery.

喹唑啉和/或查耳酮衍生物是化学科学几个领域的重要目标，主要是在药物化学和药物研究中。这篇综述的目的是将包括这两种药效基团组合成单个分子所产生的益处的文献（包括专利）中的信息系统化。与个体相比，这些杂合化合物可表现出不同的生物活性，从而产生协同或新的作用。生物活性的可变性包括抗癌，抗早老性，抗病毒和抗微生物活性。另外，基于它们的相似性，讨论了制备不同分子结构的合成方法。