Introduction: Gastrointestinal cancers have a strong association with splanchnic vein thrombosis (SVT), yet the hospitalization data is unknown. Objective and Methods: We analyzed around 78 million discharges from the 2007–2017 Nationwide Inpatient Sample with an inclusion criterion of adult patients admitted for portal or hepatic vein thrombosis as a primary diagnosis with a gastrointestinal or hepatobiliary malignancy as a secondary diagnosis. The outcomes were in-hospital mortality, complication rates, and resource utilization. Odds ratios (OR) and means were adjusted for confounders using multivariate regression analysis models. Results: Out of the total 32,324 hospitalizations for SVT, 3,220 (10%) were associated with a GI malignancy, of which hepatocellular carcinoma (HCC) and pancreatic cancer were the most common. Portal vein thrombosis accounted for 95% of these hospitalizations. Admissions for pancreatic cancer-associated SVT have increased by 7.2 times from 2007 to 2017. Patients with SVT and concomitant GI malignancies were significantly older and had a higher comorbidity score than those with SVT without GI malignancy. Risk of inpatient mortality for SVT patients were significantly higher for patients with gastric cancer (rate: 12.1%, OR 8.6, 95% CI: 1.8–39.7) and HCC (rate: 7.6%, OR 2.77, 95% CI 1.5–4.8) as compared to non-GI malignancy-related SVT. Odds of variceal bleeding were significantly higher for patients with HCC (OR 1.67, 95% CI: 1.2–2.34) than patients without GI malignancy. Conclusions: Digestive cancer-associated SVTs constitute 10% of all SVT related hospitalizations and are significantly increasing in the past decade. We report the baseline characteristics and predictors of inpatient mortality in this study.
Gastrointest Tumors

中文翻译：

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与胃肠道恶性肿瘤相关的内脏静脉血栓形成的趋势和院内结果：全国分析

简介：胃肠道癌与内脏静脉血栓形成（SVT）有很强的相关性，但住院数据尚不清楚。目标和方法：我们分析了 2007-2017 年全国住院患者样本中的约 7800 万例出院病例，纳入标准为以门静脉或肝静脉血栓形成为主要诊断入院的成年患者，以胃肠道或肝胆恶性肿瘤为次要诊断。结果是住院死亡率、并发症发生率和资源利用率。使用多元回归分析模型针对混杂因素调整优势比 (OR) 和平均值。结果：在因 SVT 住院的 32,324 人中，3,220 人 (10%) 与胃肠道恶性肿瘤有关，其中肝细胞癌 (HCC) 和胰腺癌最为常见。门静脉血栓形成占这些住院治疗的 95%。从 2007 年到 2017 年，胰腺癌相关 SVT 的入院人数增加了 7.2 倍。 SVT 和合并胃肠道恶性肿瘤患者的年龄明显高于无胃肠道恶性肿瘤的 SVT 患者。胃癌（比率：12.1%，OR 8.6，95% CI：1.8-39.7）和 HCC（比率：7.6%，OR 2.77，95% CI 1.5-4.8）的 SVT 患者住院死亡风险显着更高与非胃肠道恶性肿瘤相关的 SVT 相比。HCC 患者的静脉曲张出血几率显着更高（OR 1.67，95% CI：1.2-2。结论：消化系统癌症相关的 SVT 占所有 SVT 相关住院的 10%，并且在过去十年中显着增加。我们报告了本研究中住院患者死亡率的基线特征和预测因素。
胃肠道肿瘤