Redox Report ( IF 3.8 ) Pub Date : 2021-02-09 , DOI: 10.1080/13510002.2021.1881328 Wanda Pilch 1 , Joanna Wyrostek 2 , Anna Piotrowska 1 , Olga Czerwińska-Ledwig 1 , Roxana Zuziak 1 , Ewa Sadowska-Krępa 3 , Marcin Maciejczyk 4 , Małgorzata Żychowska 5
ABSTRACT
Objectives: In obesity, there is a shift in the pro-oxidative-antioxidant balance towards the oxidationreactions. However, it has been shown that in people with normal body composition, after a series of whole-body cryotherapy (WBC), the balance shifts in the opposite direction.
Design: The aim of the study was to assess the impact of 20 WBC treatments on blood pro-oxidative-antioxidant balance.
Interventions: Study included 14 obese (BMI > 35) and 10 non-obese volunteers.
Methods: The total antioxidative (TAS/TAC) and pro-oxidative status (TOS/TOC) in serum and activity of antioxidant enzymes in erythrocytes were determined before the first and 2 hours after the last cryostimulation.
Results: In the obese group, a significantly higher level of TOS/TOC, and its significant decrease after the WBC series, was observed. Cryotherapy had no influence on TAS/TAC level which was similar in both groups. Changes in activity of antioxidant enzymes were multidirectional. An increase in CAT activity in the obese group was observed. OSI, both before and after a series of treatments, was significantly higher in obese subjects.
Conclusions: A beneficial effect on the level of TOS/TOC and CAT activity was indicated, but the proposed number of treatments for patients with class II obesity turned out to be insufficient.
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中文翻译:
20 次全身冷冻刺激后 II 级肥胖年轻男性的血液促氧化/抗氧化平衡:初步研究
摘要
目的:在肥胖症中,促氧化-抗氧化平衡向氧化反应转变。然而,已经表明,在身体成分正常的人中,经过一系列全身冷冻疗法 (WBC),平衡会朝相反的方向移动。
设计:该研究的目的是评估 20 种 WBC 治疗对血液促氧化-抗氧化平衡的影响。
干预:研究包括 14 名肥胖(BMI > 35)和 10 名非肥胖志愿者。
方法:在第一次冷冻刺激前和最后一次冷冻刺激后2小时测定血清中的总抗氧化(TAS/TAC)和促氧化状态(TOS/TOC)和红细胞中抗氧化酶的活性。
结果:在肥胖组中,观察到 TOS/TOC 水平显着升高,并且在 WBC 系列后显着下降。冷冻疗法对 TAS/TAC 水平没有影响,两组相似。抗氧化酶活性的变化是多向的。观察到肥胖组的 CAT 活性增加。在一系列治疗前后,肥胖受试者的 OSI 显着升高。
结论:表明了对 TOS/TOC 和 CAT 活性水平的有益影响,但对 II 类肥胖患者的建议治疗数量证明是不够的。
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