Journal of Macromolecular Science Part B-Physics ( IF 1.4 ) Pub Date : 2021-02-02 , DOI: 10.1080/00222348.2021.1876975 Meiling Yi 1 , Zhihua Zhou 1, 2, 3 , Wenjuan Liu 2 , Tianlong Huang 4 , Yanmin Zhao 1 , Ping Chen 1 , Ziwei Zhou 1 , Dan Wang 1 , Chao Zhang 1 , Jianjun Fang 1
Abstract
Among drug delivery systems, polymer microspheres have been proved to be the most promising carriers during the past several years. In this paper we describe the preparation of poly(L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) random terpolymer microspheres; their in-vitro degradation behaviors, including the changes of pH value, mass loss, molecular mass and surface morphology, were investigated during various degradation periods and compared with poly(lactic-co-glycolic acid) (PLGA) microspheres. The results showed that the introduction of the ε-caprolactone (ε-CL) unit reduced the degradation rate of the PLGA polymers. Therefore, we suggest the PLLGC microspheres with controllable degradation rate could supply a wider application future in drug delivery field than pure PLGA microspheres.
中文翻译:
聚(L-丙交酯-共-乙交酯-共-ε-己内酯)微球的体外降解行为
摘要
在药物递送系统中,聚合物微球在过去几年中被证明是最有前途的载体。在本文中,我们描述了聚(L-丙交酯-共-乙交酯-共-ε-己内酯)(PLLGC)无规三元共聚物微球的制备;研究了它们在不同降解时期的体外降解行为,包括 pH 值、质量损失、分子量和表面形态的变化,并与聚(乳酸-乙醇酸共聚物)(PLGA)微球进行了比较。结果表明,ε-己内酯(ε-CL)单元的引入降低了PLGA聚合物的降解速率。因此,我们认为降解率可控的 PLLGC 微球比纯 PLGA 微球在药物递送领域具有更广泛的应用前景。