The trial was aimed at evaluating probable superiority, if any of nano zinc (NZn) over inorganic zinc (Zn) on immunity, serum minerals and T₃, T₄, and IGF-1 hormone profiles in goats. NZn was synthesized by using 0.45 M aqueous solution of Zn nitrate and 0.9 M aqueous solution of sodium hydroxide (average particle size 74 nm). Twenty-four male goats were grouped into four groups as per their body weight and were supplemented with either a basal diet with concentrate and straw at 50:50 ratio (Negative control, NC) alone or supplemented with 50 mg/kg Zn (Control) from inorganic Zn source, that is ZnO (IZn-50), 50 mg/kg Zn from NZn (NZn-50) or 25 mg/kg Zn from NZn (NZn-25). No change was observed in thyroid hormone status on zero and 90th day of experimental feeding, but NZn supplementation improved (p < 0.05) IGF-1 level on 90th day serum samples. Zn supplementation improved the humoral immunity in all the groups irrespective of the source. Similarly, cell-mediated immunity (CMI) measured by skinfold thickness after injecting Con-A, was also improved in Zn supplemented groups than control at 6, 12 and 48 h of incubation. NZn-50 animals showed highest HI (haemagglutination inhibition) titre as well as skin thickness. The (cluster of differentiation in %) was more (p < 0.05) in Zn supplemented groups. NZn-50 showed higher (p < 0.05) count than NC and similar (p > 0.05) to IZn-50 and NZn-25 groups without affecting (p > 0.05) the ratio of , among the treatment groups. Thus, NZn supplementation at 25 mg/kg had similar immunity and serum T₃, T₄ and IGF-1 profiles compared with IZn at 50 mg/kg dose.

中文翻译：

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山羊（Capra hircus）日粮中的纳米锌补充剂可提高免疫力、血清锌谱和 IGF-1 激素，而不会影响甲状腺激素

该试验旨在评估纳米锌 (NZn) 在免疫、血清矿物质和 T ₃、T ₄方面可能优于无机锌 (Zn)和山羊的 IGF-1 激素谱。通过使用 0.45 M 硝酸锌水溶液和 0​​.9 M 氢氧化钠水溶液（平均粒径 74 nm）合成 NZn。将 24 只雄性山羊按其体重分为四组，并分别以 50:50 的比例添加精料和稻草的基础日粮（阴性对照，NC）或补充 50 mg/kg Zn（对照）来自无机锌源，即 ZnO (IZn-50)，来自 NZn (NZn-50) 的 50 mg/kg Zn 或来自 NZn (NZn-25) 的 25 mg/kg Zn。实验喂养第 0 天和第 90 天甲状腺激素状态没有变化，但补充 NZn 有所改善（p < 0.05) 第 90 天血清样品的 IGF-1 水平。无论来源如何，补锌都能提高所有组的体液免疫。类似地，在注射 Con-A 后通过皮褶厚度测量的细胞介导的免疫 (CMI)，在 6、12 和 48 小时的孵育时间，锌补充组也比对照组有所改善。NZn-50 动物表现出最高的 HI（血细胞凝集抑制）滴度以及皮肤厚度。的（以％分化簇）是以上（p  <0.05）中的Zn补充组。NZn-50 显示出比 NC更高的 ( p  < 0.05)计数并且与 IZn-50 和 NZn-25 组相似 ( p > 0.05)，而不影响 ( p  > 0.05) 的比率，治疗组之间。因此，与 50 mg/kg 剂量的 IZn 相比，25 mg/kg 的 NZn 补充剂具有相似的免疫力和血清 T ₃、T ₄和 IGF-1 特征。