Aedes aegypti is a remarkably effective mosquito vector of epidemiologically important arboviral diseases including dengue fever, yellow fever and Zika. The present spread of resistance against pyrethroids, the primary insecticides used for mosquito control, in global populations of this species is of great concern. The voltage‐gated sodium channel (VGSC) in the nervous system is the known target site of pyrethroids in insects. Past studies have revealed several amino‐acid substitutions in this channel that confer pyrethroid resistance, which are known as knockdown resistance (kdr) mutations.

中文翻译：

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埃及伊蚊电压门控钠通道的第二个拟除虫菊酯受体上的第一个自然取代

埃及伊蚊是一种流行病学上重要的虫媒病毒疾病（包括登革热，黄热病和寨卡病毒）的非常有效的蚊子。目前在该物种的全球种群中对拟除虫菊酯（用于控制蚊子的主要杀虫剂）的抗药性正在蔓延。神经系统中的电压门控钠通道（VGSC）是拟除虫菊酯在昆虫中的已知靶位。过去的研究已经揭示了该通道中的多个氨基酸取代基赋予了拟除虫菊酯抗性，这被称为敲低抗性（kdr）突变。