Endocannabinoids have been implicated in the pathophysiology of Major Depressive Disorder (MDD) and might represent potential targets for therapeutic intervention. Objectives of the study were: (1) to measure plasma levels of endocannabinoids in a group of antidepressant-free depressed outpatients; (2) to explore their relationship with the severity of depressive symptoms as subjectively perceived by the patients; and (3) to investigate the effect of the selective serotonin reuptake inhibitor escitalopram on endocannabinoid levels.

中文翻译：

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血浆 2-花生四烯酸甘油水平与抑郁症的主观严重程度呈负相关

内源性大麻素与重度抑郁症 (MDD) 的病理生理学有关，可能代表治疗干预的潜在目标。该研究的目的是：（1）测量一组未使用抗抑郁药的抑郁门诊患者的血浆内源性大麻素水平；(2) 探讨其与患者主观感知的抑郁症状严重程度的关系；(3) 研究选择性5-羟色胺再摄取抑制剂依他普仑对内源性大麻素水平的影响。