Introduction

Central nervous system (CNS) metastasis from nasopharyngeal carcinoma (NPC) is rare and presents with high morbidity and mortality. As a rare entity, a few patients with CNS metastasis from NPC have been reported, and no studies were available on treatment and prognosis. Based on our clinical experience, early diagnosis with incorporation of a clear palliative plan is imperative in providing holistic care for patients with locally-invasive and metastatic nasopharyngeal carcinoma.

Case report

Our study reports a case of a 48-year-old Filipino male with known NPC Stage IVB who developed acute symptoms of constipation, urinary retention, and bilateral lower limb weakness and numbness. Magnetic resonance imaging showed intramedullary lesions in multiple segments of the spinal cord. Steroid and radiotherapy of the spine were initiated with noted transient improvement of the motor strength. Subsequently, he developed cancer-related stroke. The patient progressively deteriorated despite best medical care.

中文翻译：

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罕见鼻咽癌髓内脊髓转移病例

介绍

鼻咽癌 (NPC) 的中枢神经系统 (CNS) 转移是罕见的，并且具有高发病率和死亡率。作为一种罕见的实体，已经报道了少数鼻咽癌中枢神经系统转移的患者，但没有关于治疗和预后的研究。根据我们的临床经验，早期诊断并结合明确的姑息治疗计划对于为局部浸润性和转移性鼻咽癌患者提供整体护理至关重要。

案例报告

我们的研究报告了一名 48 岁的菲律宾男性，患有已知的 NPC IVB 期，他出现便秘、尿潴留和双侧下肢无力和麻木的急性症状。磁共振成像显示脊髓多节段的髓内病变。脊柱的类固醇和放射治疗开始时有明显的运动强度的短暂改善。随后，他患上了与癌症相关的中风。尽管得到了最好的医疗护理，患者的病情逐渐恶化。