ABSTRACT Precision medicine approaches to depression argue for the assessment of individual client profiles of the two major diagnostic criteria of depressed mood and anhedonia. To explore this suggestion, 1,513 males and 1,348 females aged between 55 and 87 years from Newcastle, Australia, completed the Center for Epidemiological Studies-Depression Scale (CESD). Total CESD score and the two sets of scores gradually increased with age; females had significantly higher scores on total CESD and the two subsets of scores. Anhedonia showed greater prevalence than depressed mood and also increased from age 70 years, whereas depressed mood remained fairly stable until age 80 years. Treatment efficacy for depression may benefit from consideration of individual client profiles on these two aspects of depression.

中文翻译：

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老年人情绪低落与狂躁症的患病率：对临床实践的影响

摘要精准医学治疗抑郁症的方法主张对抑郁和情绪低下的两个主要诊断标准的个体患者特征进行评估。为了探讨这一建议，来自澳大利亚纽卡斯尔的年龄在55至87岁之间的1,513名男性和1,348名女性完成了流行病学研究中心抑郁量表（CESD）。总的CESD分数和两组分数随着年龄的增长而逐渐增加；女性在总的CESD和分数的两个子集上的得分明显更高。Anhedonia的患病率比沮丧的情绪高，并且从70岁开始也有所增加，而沮丧的情绪直到80岁仍然保持稳定。抑郁症的治疗功效可能得益于对抑郁症这两个方面的个体服务对象的考虑。