Quantitative ultrasound (QUS) has emerged as a viable tool in diagnosing and staging the onset and progression of various diseases. Within the field of QUS, shear wave elastography (SWE) has emerged as the clinical standard for quantifying and correlating the stiffness of tissue to its underlying pathology. Despite its widespread use, SWE suffers from drawbacks that limit its widespread clinical use; among these are low-frame rates, long settling times, and high sensitivity to operating conditions. Longitudinal speed of sound (SOS) has emerged as a viable alternative to SWE. We propose a framework to obtain 2D sound speed maps using a commercial ultrasound probe. A commercial ultrasound probe is localized in space and used to scan a domain of interest from multiple vantage points; the use of a reflector at the far end of the domain allows us to measure the round trip travel times to and from it. The known locations of the probe and the measured travel times are used to estimate the depth and inclination of the reflector as well as the unknown sound speed map. The use of multiple looks increases the effective aperture of the ultrasound probe and allows for a higher fidelity reconstruction of sound speed maps. We validate the framework using simulated and experimental data and propose a rigorous framework to quantify the uncertainty of the estimated sound speed maps.

定量超声（QUS）已成为诊断和分期各种疾病的发作和发展的可行工具。在QUS领域，剪切波弹性成像（SWE）已成为量化组织的硬度并将其与其潜在病理联系起来的临床标准。尽管其广泛使用，但SWE仍具有限制其广泛临床应用的缺点。其中包括低帧速率，长稳定时间以及对工作条件的高度敏感性。纵向声速（SOS）已经成为SWE的可行替代方案。我们提出了使用商业超声探头获得二维声速图的框架。商业超声探头位于空间中，用于从多个有利位置扫描感兴趣的区域。在域的远端使用反射器使我们能够测量往返于该域的往返时间。探头的已知位置和测得的行进时间用于估计反射器的深度和倾斜度以及未知的声速图。多外观的使用增加了超声探头的有效孔径，并允许以更高的保真度重建声速图。我们使用模拟和实验数据验证该框架，并提出一个严格的框架来量化估计声速图的不确定性。多外观的使用增加了超声探头的有效孔径，并允许以更高的保真度重建声速图。我们使用模拟和实验数据验证该框架，并提出一个严格的框架来量化估计声速图的不确定性。多外观的使用增加了超声探头的有效孔径，并允许以更高的保真度重建声速图。我们使用模拟和实验数据验证该框架，并提出一个严格的框架来量化估计声速图的不确定性。