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Energy dependency of dose response function of a Gd2O2S scintillator detection system for spot-scanning carbon-ion and proton radiotherapy
Radiation Measurements ( IF 2 ) Pub Date : 2021-02-08 , DOI: 10.1016/j.radmeas.2021.106538
Yongqiang Li , Wenchien Hsi , Jun Zhao , Zhi Chen , Wenbo Xie

To ensure quality assurance (QA) of scanning proton and carbon-ion therapy doses, an efficient and reliable method to measure the energy dependency of the dose response function (DRF) of an optical scintillator detection system (OSDS), is required. We present a calibration process that corrects the non-linear sensitivity of the imager's electronic readings into linear light intensities. After calibration, a digital readout of green colored stimulated-light emission (SLE) are converted to nominal SLE (N_SLE). The slope of N_SLE as a linear function of dose is labelled as K-factor. The K-factors for 7 energies of carbon-ion and proton have been measured. For the highest (424.89 MeV/u) and lowest (97.87 MeV/u) energies of carbon-ion, the K-factors are 0.96 and 0.76 N_SLE/Gy. For the highest (218.56 MeV) and lowest (53.04 MeV) energies of protons, the K-factors are 0.96 and 0.86 N_SLE/Gy. The variation of K-factor for its energy dependence are 18% and 11% between lowest and highest energies of carbon-ion and proton beam respectively. Similar trending of the K-factor was seen for the red and blue colors with respect to the green color channel, although the signal magnitude was lower for the red channel. The OSDS dose response is weakly dependent on the energy of the carbon-ion and proton beams regardless of color channel. The energy-dependency of DRF and interactive capability of OSDS can be used to create efficient dosimetry tools to measure data for spot-scanning carbon-ion and proton radiotherapy.



中文翻译:

用于点扫描碳离子和质子放射治疗的Gd 2 O 2 S闪烁体检测系统剂量响应函数的能量依赖性

为了确保扫描质子和碳离子治疗剂量的质量保证(QA),需要一种有效,可靠的方法来测量光学闪烁体检测系统(OSDS)的剂量响应函数(DRF)的能量依赖性。我们提出了一种校准过程,可以将成像器电子读数的非线性灵敏度校正为线性光强度。校准后,绿色激发光(SLE)的数字读数将转换为标称SLE(N_SLE)。N_SLE的斜率作为剂量的线性函数,被标记为K因子。已经测量了碳离子和质子的7个能量的K因子。对于碳离子的最高能量(424.89 MeV / u)和最低能量(97.87 MeV / u),K​​因子分别为0.96和0.76 N_SLE / Gy。对于质子的最高(218.56 MeV)和最低(53.04 MeV)能量,K因子为0.96和0.86 N_SLE / Gy。在碳离子和质子束的最低和最高能量之间,K因子的能量依赖性变化分别为18%和11%。尽管红色通道的信号幅度较低,但相对于绿色通道,红色和蓝色的K因子趋势相似。OSDS剂量响应几乎不依赖于碳离子束和质子束的能量,而与颜色通道无关。DRF的能量依赖性和OSDS的交互功能可用于创建有效的剂量学工具,以测量用于点扫描碳离子和质子放射疗法的数据。尽管红色通道的信号幅度较低,但相对于绿色通道,红色和蓝色的K因子趋势相似。OSDS剂量响应几乎不依赖于碳离子束和质子束的能量,而与颜色通道无关。DRF的能量依赖性和OSDS的交互功能可用于创建有效的剂量学工具,以测量用于点扫描碳离子和质子放射疗法的数据。尽管红色通道的信号幅度较低,但相对于绿色通道,红色和蓝色的K因子趋势相似。OSDS剂量响应几乎不依赖于碳离子束和质子束的能量,而与颜色通道无关。DRF的能量依赖性和OSDS的交互功能可用于创建有效的剂量学工具,以测量用于点扫描碳离子和质子放射疗法的数据。

更新日期:2021-02-08
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