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Scientific rationale of hospital discharge as a sustainable source of irrigation water: Detection, phytological assessment and toxicity verification
Process Safety and Environmental Protection ( IF 7.8 ) Pub Date : 2021-02-08 , DOI: 10.1016/j.psep.2021.01.051
Y.N. Chow , L.K. Lee , K.Y. Foo

Hospital discharge (HD) represents the primary point source of pharmaceutical components that may constitute not only a sharp risk of phytotoxic effects in food crops, but leaving behind the toxicity implications to the environment. The present work has been oriented to the scientific assessment of pharmaceutical compounds in HD. The phenological, physiological, and morphological changes, oxidative stress biomarkers, antioxidative responses, bioaccumulation and bioconcentration factor in relation to different concentrations of HD-induced irrigation in Ipomoea aquatica were evaluated; while the cytotoxicity and genotoxicity on human hepatocellular carcinoma (HepG2) cell were assessed. Acetaminophen, metoprolol, atenolol, enalapril, and metformin were predominantly detected in the raw HD and bioaccumulated in I. aquatica. Concentration-dependent phenological inhibition, chlorophylls reductions, morphological distortions, reactive oxygen species generation, and antioxidant enzymes upregulation were recorded in the HD-irrigated I. aquatica. Drastic reductions in cell viability and increase of tail damage and tail moment indicated the metabolic alterations of mitochondrial function, and deoxyribonucleic acid (DNA) damage via oxidative stress and DNA adducts formation in the HD-treated groups. The diluted HD at 5% and 10% could be feasibly reused for food crops irrigation, verified by the negligible phytotoxic implications in the plant model, bioaccumulation, and cytotoxic and genotoxic effects in HepG2 cell.



中文翻译:

医院出水作为可持续灌溉水源的科学依据:检测,植物学评估和毒性验证

医院出院(HD)代表了药物成分的主要来源,这些成分不仅可能构成对粮食作物产生植物毒性作用的重大风险,而且还会对环境造成影响。目前的工作是针对高清药物成分的科学评估。评估了不同浓度的高加索水I菜灌溉后的物候,生理和形态变化,氧化应激生物标志物,抗氧化反应,生物积累和生物富集因子;同时评估了对人肝细胞癌(HepG2)细胞的细胞毒性和遗传毒性。对乙酰氨基酚,美托洛尔,阿替洛尔,依那普利和二甲双胍主要在原始HD中检出,并在一,菜类。在高清灌溉的水生I. atictica中记录了浓度依赖性的物候抑制,叶绿素减少,形态畸变,活性氧生成和抗氧化酶上调。在HD处理组中,细胞活力的急剧下降以及尾巴损伤和尾矩的增加表明线粒体功能的代谢改变,以及通过氧化应激和脱氧核糖核酸(DNA)形成的脱氧核糖核酸(DNA)损伤。稀释的HD(分别为5%和10%)可以合理地用于粮食作物灌溉,这已通过对植物模型,生物蓄积以及HepG2细胞的细胞毒性和遗传毒性影响的微不足道的验证而得到证实。

更新日期:2021-02-08
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