Co-occurrence of bacterial infections with type 2 diabetes (T2D) is a global problem. Melioidosis caused by Burkholderia pseudomallei is 10 times more likely to occur in patients with T2D, than in normoglycemic individuals. Using an experimental model of T2D, we observed that greater susceptibility in T2D was due to differences in proportions of infiltrating leucocytes and reduced levels of MCP-1, IFN-γ and IL-12 at sites of infection within 24 h post-infection. However, by 72 h the levels of inflammatory cytokines and bacteria were markedly higher in visceral tissue and blood in T2D mice. In T2D, dysregulated early immune responses are responsible for the greater predisposition to B. pseudomallei infection.

细菌感染与 2 型糖尿病 (T2D) 的同时发生是一个全球性问题。由假鼻疽伯克霍尔德菌引起的类鼻疽在 T2D 患者中发生的可能性是血糖正常个体的 10 倍。使用 T2D 的实验模型，我们观察到 T2D 的更高易感性是由于浸润白细胞比例的差异以及感染后 24 小时内感染部位 MCP-1、IFN-γ 和 IL-12 的水平降低。然而，到 72 小时，T2D 小鼠内脏组织和血液中的炎性细胞因子和细菌水平显着升高。在 T2D 中，失调的早期免疫反应是导致更容易感染B.pseudomallei 的原因。