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Hydrodynamic optimization for design and operating parameters of an innovative continuous-flow miniaturized MFC biosensor
Chemical Engineering Science ( IF 4.7 ) Pub Date : 2021-02-08 , DOI: 10.1016/j.ces.2021.116505
Nan Xiao , Bing Wang , Jinhui Jeanne Huang

An innovative continuous-flow miniaturized MFC-based biosensor was developed in this work. The substrate distribution inside sensor channels has important influence in the biofilm uniformity, and consequently in the sensor performance. However, such miniaturized device is too small in dimension to be directly measured. In this work, computational fluid dynamics (CFD) was chosen to simulate the diffusion of substrate and its concentration distribution in sensors, with different channel dimensions and various flow rates. CFD results were in good agreement with the experimental data. Results demonstrated that channel length has a significant influence on the stability and sensitivity of MFC-based biosensor whilst the detection range was mostly influenced by the channel width. It found that MFC sensor with 10 mm × 10 mm dimension and 50 μL/min flow rate could have the most uniform substrate distribution for 0–492 mg/L BOD. The CFD method developed in this research could also be utilized in the calibration of MFC-based sensor.



中文翻译:

创新的连续流小型化MFC生物传感器的设计和操作参数的流体动力学优化

在这项工作中开发了一种创新的连续流小型化基于MFC的生物传感器。传感器通道内部的基质分布对生物膜的均匀性以及传感器性能具有重要影响。然而,这种小型化装置的尺寸太小而不能直接测量。在这项工作中,选择了计算流体动力学(CFD)来模拟基质的扩散及其在传感器中的浓度分布,具有不同的通道尺寸和各种流速。CFD结果与实验数据吻合良好。结果表明通道长度对基于MFC的生物传感器的稳定性和灵敏度有重要影响,而检测范围主要受通道宽度影响。结果发现,对于0-492 mg / L BOD,尺寸为10 mm×10 mm且流量为50μL/ min的MFC传感器具有最均匀的基质分布。在这项研究中开发的CFD方法也可用于基于MFC的传感器的校准。

更新日期:2021-02-19
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