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Not All Tumor-Infiltrating CD8+ T Cells Are Created Equal
Cancer Cell ( IF 50.3 ) Pub Date : 2021-02-08 , DOI: 10.1016/j.ccell.2021.01.015
Werner Held 1 , Daniel E Speiser 1
Affiliation  

Adoptive cell immunotherapy using in vitro expanded autologous tumor-infiltrating lymphocytes has the potential to mediate durable remission of certain types of cancer. A recent paper in Science shows that complete and durable control of metastatic melanoma requires the infusion of tumor-specific CD8+ T cells that have stem-cell-like properties.



中文翻译:

并非所有肿瘤浸润的 CD8+ T 细胞都是平等的

使用体外扩增的自体肿瘤浸润淋巴细胞的过继细胞免疫疗法有可能介导某些类型癌症的持久缓解。最近发表在《科学》上的一篇论文表明,要完全持久地控制转移性黑色素瘤,需要输注具有干细胞样特性的肿瘤特异性 CD8 + T 细胞。

更新日期:2021-02-08
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