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A Thermodynamic Micellization and Hemolysis Evaluation of Polysorbate Surfactants in Combination with Short-Chain Alcohols
Journal of Cluster Science ( IF 2.8 ) Pub Date : 2021-02-08 , DOI: 10.1007/s10876-021-02012-9
Soodeh Salarpour , Majid Rajaee , Ehsan Mohajeri , Maryam Hobab , Mandana Ohadi , Ibrahim M. Banat , Gholamreza Dehghannoudeh

Surface active agents have been used in many pharmaceutical formulations for different purposes as penetration enhancers. In this study, the penetration enhancement activity of four nonionic surfactants from polyoxyethylene sorbitan fatty acid esters alone and in combination with some short-chain alcohols on red blood cells were investigated. Hemolysis at different concentrations of each nonionic surfactant (0.1, 0.2, 0.5, 1, and 2%) and ethanol, isopropyl alcohol, glycerol, and propylene glycol (0.5, 1, 2, 5, and 10% w/v) were investigated. Critical micelle concentration (CMC) and micellization thermodynamic parameters of tween 80 in presence of ethanol and glycerol at different concentrations were determined. The influence of the ethanol and glycerol on nonionic surfactant micelle formation was evaluated by determining CMC and micellization thermodynamic parameters of tween80 at different concentrations of alcohol-tween mixtures. The mixture of Tween 20 and glycerol have the lowest hemolytic activity while tween 80-ethanol mixture has the highest hemolysis activity. The self-aggregation of surfactant monomers was affected by short-chain alcohols. The structure breaking ability of alcohol and their interactions with the hydrophilic-hydrophobic groups of surfactants might be the main factors for changing the micelle formation. The CMCs of tween 80 was incremented by increasing the concentration of alcohol. The results indicated that by adding and increasing short chain alcohols the CMCs increased also the CMCs were increasing through raising the temperature (while in the presents of surfactants alone the CMCs decreased by raising temperature).



中文翻译:

短链醇与聚山梨酯表面活性剂的热力学胶束化和溶血性评估

表面活性剂已在许多药物制剂中用作渗透促进剂,用于不同目的。在这项研究中,研究了聚氧乙烯失水山梨糖醇脂肪酸酯中的四种非离子表面活性剂单独以及与一些短链醇结合在红细胞上的渗透增强活性。研究了每种浓度的非离子表面活性剂(0.1、0.2、0.5、1和2%)和乙醇,异丙醇,甘油和丙二醇(0.5、1、2、5和10%w / v)在不同浓度下的溶血作用。确定了在不同浓度的乙醇和甘油存在下,吐温80的临界胶束浓度(CMC)和胶束化热力学参数。乙醇和甘油对非离子型表面活性剂胶束形成的影响通过确定tween80在不同浓度的酒精-吐温混合物中的CMC和胶束化热力学参数来评估。Tween 20和甘油的混合物的溶血活性最低,而Tween 80-乙醇混合物的溶血活性最高。表面活性剂单体的自聚集受到短链醇的影响。醇的结构破坏能力及其与表面活性剂亲水-疏水基团的相互作用可能是改变胶束形成的主要因素。吐温80的CMC通过增加酒精浓度来增加。

更新日期:2021-02-08
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