This study investigated the effects of aerobic training and extract of Pistacia-atlantica (Baneh) as a plant with rich fatty acids, on tissue nesfatin-1/nucleobindin-2 and ghrelin gene expression, plasma high- and low-density lipoprotein, tissue/plasma total cholesterol and triglyceride concentrations in female rats. 20 Wistar rats were randomly assigned to saline-control, saline-training, Baneh-control, and Baneh-training groups. The training groups were given a specific exercise on a motor-driven treadmill for 8 weeks. Nesfatin-1/nucleobindin-2 and ghrelin mRNA expressions were detected by Real-time PCR method. According to the results, the trained rats had higher nesfatin-1 mRNA expressions in liver and visceral fat and liver estradiol concentration but their liver ghrelin mRNA expressions were lower compared to the control rats. Baneh-treated rats had lower nesfatin-1 mRNA expressions in liver and visceral fat and plasma HDL-C concentration, but their plasma estradiol concentrations were significantly higher. Moreover, liver estradiol concentration and liver ghrelin mRNA expression were negatively correlated, whereas the correlation between plasma estradiol and HDL-C concentrations and nesfatin-1 mRNA expression in visceral fat was significantly positive. Generally, exercise and a high-fat diet induced changes in liver ghrelin, nesfatin-1 mRNA expression, liver estradiol level, and nesfatin-1 in visceral fat, nesfatin-1 expression in liver and visceral fat, liver glucose, plasma HDL-C, and estradiol.

中文翻译：

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耐力训练和中草药补充对组织nesfatin-1 / nucleobindin-2和ghrelin mRNA表达的影响

这项研究调查了有氧训练和富含脂肪酸的植物黄连木（Baneh）提取物对组织nesfatin-1 / nucleobindin-2和ghrelin基因表达，血浆高密度和低密度脂蛋白，组织/雌性大鼠的血浆总胆固醇和甘油三酸酯浓度。将20只Wistar大鼠随机分为生理盐水对照组，生理盐水训练组，Baneh对照组和Baneh训练组。培训小组在电动跑步机上进行了为期8周的特定锻炼。实时荧光定量PCR检测Nesfatin-1 / nucleobindin-2和ghrelin mRNA的表达。根据结果​​，受训练的大鼠在肝脏和内脏脂肪和肝雌二醇浓度中的nesfatin-1 mRNA表达较高，但与对照组相比，它们的肝脏生长素释放肽mRNA表达较低。Baneh处理的大鼠肝脏和内脏脂肪和血浆HDL-C浓度的nesfatin-1 mRNA表达较低，但血浆雌二醇浓度明显较高。此外，肝雌二醇浓度和生长激素释放素mRNA表达呈负相关，而内脏脂肪中血浆雌二醇和HDL-C浓度与nesfatin-1 mRNA表达之间呈显着正相关。通常，运动和高脂饮食会引起内脏脂肪中ghrelin，nesfatin-1 mRNA表达，肝脏雌二醇水平和nesfatin-1的变化，内脏脂肪中nesfatin-1的表达，肝糖，血浆HDL-C的变化和雌二醇。此外，肝雌二醇浓度和生长激素释放素mRNA表达呈负相关，而内脏脂肪中血浆雌二醇和HDL-C浓度与nesfatin-1 mRNA表达之间呈显着正相关。通常，运动和高脂饮食会引起内脏脂肪中ghrelin，nesfatin-1 mRNA表达，肝脏雌二醇水平和nesfatin-1的变化，内脏脂肪中nesfatin-1的表达，肝糖，血浆HDL-C的变化和雌二醇。此外，肝雌二醇浓度和生长激素释放素mRNA表达呈负相关，而内脏脂肪中血浆雌二醇和HDL-C浓度与nesfatin-1 mRNA表达之间呈显着正相关。通常，运动和高脂饮食会引起内脏脂肪中ghrelin，nesfatin-1 mRNA表达，肝脏雌二醇水平和nesfatin-1的变化，内脏脂肪中nesfatin-1的表达，肝糖，血浆HDL-C的变化和雌二醇。