Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histone crotonylation at DNA regulatory elements plays an important role in the activation of gene transcription. However, among others, we have shown that elevated cellular crotonylation levels result in the inhibition of endocytosis-related gene expression and pro-growth gene expression, implicating the complexity of histone crotonylation in gene regulation. Therefore, it is important to understand how histone crotonylation is regulated and how it, in turn, regulates the expression of its target genes. In this review, we summarize the regulatory factors that control histone crotonylation and discuss the role of different histone crotonylation sites in regulating gene expression, while providing novel insights into the central role of histone crotonylation in gene regulation.

中文翻译：

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组蛋白巴豆酰化中心基因调控

组蛋白巴豆酰化是最近描述的一种翻译后修饰，它发生在多个已确定的组蛋白赖氨酸巴豆酰化位点。越来越多的研究表明，DNA 调控元件上的组蛋白巴豆酰化在基因转录的激活中起重要作用。然而，除其他外，我们已经表明，升高的细胞巴豆酰化水平会导致内吞相关基因表达和促生长基因表达的抑制，这表明组蛋白巴豆酰化在基因调控中的复杂性。因此，重要的是要了解组蛋白巴豆酰化是如何被调节的，以及它又如何调节其靶基因的表达。在本次审查中，