This work is focused on the study of the effect of cholesterol on the properties of vesicular membranes of ionic amphiphilic pairs at different temperatures. The hexadecyltrimethylammonium-dodecyl sulfate ionic amphiphilic pair system with the addition of 10 mol % dioctadecyldimethylammonium chloride was chosen for a detailed study of vesicle properties. A large range of cholesterol concentrations (0–73 mol %) in the temperature range 10–80 °C was studied. Under these conditions, the size distribution, the membrane fluidity, and the surface layer were monitored together with the change in the mobility of water in the surface layer. Obtained quantities were correlated with each other and combined into appropriate graphs. It was found that in stable systems that meet the condition of unimodal size distribution with a PDI value lower than 0.3, temperature has virtually no effect on the size of vesicular systems. On the contrary, when studying the hydration and fluidity of the membrane, significant changes in these parameters were found, which, however, do not affect the short-term stability of these vesicular systems. The presented results thus indicate the possibility of adjusting the composition of the vesicular system in terms of fluidity and membrane hydration while maintaining short-term stability and size distribution.

中文翻译：

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胆固醇对不同温度下阳离子对两亲泡囊膜性能的影响

这项工作的重点是研究胆固醇在不同温度下对两性离子对的囊泡膜性能的影响。选择十六烷基三甲基铵-十二烷基硫酸盐离子两亲性对体系，并添加10 mol％的二十八烷基二甲基氯化铵用于详细研究囊泡性能。研究了在10–80°C的温度范围内的大范围胆固醇浓度（0–73 mol％）。在这些条件下，监测尺寸分布，膜流动性和表层以及表层中水的迁移率变化。获得的数量相互关联，并组合成适当的图形。发现在满足单峰尺寸分布条件且PDI值低于0.3的稳定系统中，温度实际上对水泡系统的大小没有影响。相反，当研究膜的水合作用和流动性时，发现这些参数发生了显着变化，但是，这并不影响这些囊泡系统的短期稳定性。因此，所呈现的结果表明在保持短期稳定性和尺寸分布的同时，就流动性和膜水合作用调节水泡系统组成的可能性。