The three-component reaction of (E)-1,5-diarylpent-4-ene-1,3-diones, isatins, and (thia)proline in i-PrOH at room temperature proceeds regio- and stereoselectively leading to the formation of spiro[(thia)pyrrolizidine-3,3'-oxindoles] with the 1,3-dicarbonyl moiety in the (thia)pyrrolizidine ring. Subsequent treatment of these tetracyclic products with arylhydrazine hydrochlorides under reflux in the EtOH–AcOH system gave 5-substituted 1,3-diaryl-1H-pyrazoles in high yields.

中文翻译：

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1,5-二芳基戊四烯-1,3-二酮在螺[[thia] pyrolrolizidine-3,3'-oxindoles]和1,3-diaryl-5-spiro [oxindole-3,3'的合成中-吡咯并齐丁-2'-基] -1 H-吡唑类

在室温下，i -PrOH中的（E）-1,5-二芳基戊-4-烯-1,3-二酮，靛红和脯氨酸的三组分反应进行区域选择性和立体选择性反应，从而形成螺[（thia）pyrrolizidine-3,3'-oxindoles]在（thia）吡咯烷环上有1,3-二羰基部分。在EtOH-AcOH体系中，在回流下用芳基肼盐酸盐对这些四环产物进行后续处理，可以高产率获得5取代的1,3-二芳基-1 H-吡唑。