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Effect of pH on Isoliquiritigenin (ISL) fluorescence in lipo- polymeric system and metallic nanosystem
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.4 ) Pub Date : 2021-02-04 , DOI: 10.1016/j.saa.2021.119545
Phebee Angeline , Aswathi Thomas , Sri Amruthaa Sankaranarayanan , Aravind Kumar Rengan

Flavonoids have various medicinal properties such as anti-inflammatory, anti-oxidant, anti-cancer, antiviral. Yet, the fluorescent properties of flavonoids are less explored and termed as autofluorescence in general. This study investigates the fluorescence properties of Isoliquiritigenin (ISL) in various alkaline conditions. The maximum fluorescence emission was obtained at pH 12 on excitation wavelength of 440 nm. Theoretical and experimental investigation on the shift in UV–Vis absorbance spectra, upon the variation in pH, performed, indicated deprotonation as the cause. PEG-based stable liposome carrier, with an internal alkaline environment (LIP-ISL-NaOH) that aids in flavonoid fluorescence, was synthesized using a modified thin-film hydration method. The hydrodynamic size of the liposome synthesized was in the range of 50–70 nm. PEG, on the addition, found maintaining the alkaline environment in the internal chamber of the lipo-polymer system, helps the LIP-ISLNaOH nanosystem to exhibit fluorescence irrespective of the suspension pH. Further, reducing property of ISL was used for the synthesis of Au nanoclusters to achieve theranostic nature.



中文翻译:

pH值对脂聚合物和金属纳米系统中异黄体生成素(ISL)荧光的影响

类黄酮具有多种医学特性,例如抗炎,抗氧化,抗癌,抗病毒。然而,类黄酮的荧光性质很少被探索,并且通常被称为自发荧光。这项研究调查了在各种碱性条件下异寡糖原蛋白(ISL)的荧光性质。在440 nm的激发波长下,在pH 12下获得最大的荧光发射。对pH值变化进行UV-Vis吸收光谱变化的理论和实验研究表明,引起质子化的原因。使用改良的薄膜水化方法合成了具有内部碱性环境(LIP-ISL-NaOH)的,基于PEG的稳定脂质体载体,该内部碱性环境有助于类黄酮荧光。合成的脂质体的流体动力学尺寸为50-70 nm。聚乙二醇 此外,发现在脂聚合物系统内部腔室中保持碱性环境,有助于LIP-ISLNaOH纳米系统显示荧光,而与悬浮液pH无关。此外,ISL的还原性质用于合成Au纳米团簇以实现治疗诊断性质。

更新日期:2021-02-15
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