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White matter microstructural differences underlying beta oscillations during speech in adults who stutter
Brain and Language ( IF 2.5 ) Pub Date : 2021-02-04 , DOI: 10.1016/j.bandl.2021.104921
Fatemeh Mollaei 1 , Anna Mersov 2 , Merron Woodbury 3 , Cecilia Jobst 3 , Douglas Cheyne 4 , Luc De Nil 5
Affiliation  

The basal ganglia-thalamocortical (BGTC) loop may underlie speech deficits in developmental stuttering. In this study, we investigated the relationship between abnormal cortical neural oscillations and structural integrity alterations in adults who stutter (AWS) using a novel magnetoencephalography (MEG) guided tractography approach. Beta oscillations were analyzed using sensorimotor speech MEG, and white matter pathways were examined using tract-based spatial statistics (TBSS) and probabilistic tractography in 11 AWS and 11 fluent speakers. TBSS analysis revealed overlap between cortical regions of increased beta suppression localized to the mouth motor area and a reduced fractional anisotropy (FA) in the AWS group. MEG-guided tractography showed reduced FA within the BGTC loop from left putamen to subject-specific MEG peak. This is the first study to provide evidence that structural abnormalities may be associated with functional deficits in stuttering and reflect a network deficit within the BGTC loop that includes areas of the left ventral premotor cortex and putamen.



中文翻译:

口吃成人说话时β振荡的白质微观结构差异

基底神经节-丘脑皮质 (BGTC) 循环可能是发育性口吃中语言缺陷的基础。在这项研究中,我们使用新型脑磁图 (MEG) 引导的纤维束成像方法调查了口吃 (AWS) 成人的异常皮层神经振荡与结构完整性改变之间的关系。使用感觉运动语音 MEG 分析 Beta 振荡,并使用基于束的空间统计 (TBSS) 和概率束成像在 11 个 AWS 和 11 个流利的扬声器中检查白质通路。TBSS 分析显示,在 AWS 组中,位于嘴部运动区域的 β 抑制增加的皮质区域与各向异性分数 (FA) 降低之间存在重叠。MEG 引导的纤维束成像显示从左壳核到受试者特定的 MEG 峰值的 BGTC 循环内 FA 减少。

更新日期:2021-02-04
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