Abstract

Granules and microparticles containing essential oils from Varronia verbenacea and Achyrocline satureioides were prepared, dried and evaluated in vitro by measuring releasing profiles, particle size, oil load, density, humidity and water activity at time zero and 60 days after production. Comparisons were also made using hard gelatin capsules. Measurements showed a significant decrease in oil load for the spray-dried particles compared to granules, and the desiccator-dried granules proved to maintain the highest oil content over the 60-day period. Moreover, gelatin capsules reduced oil losses, which is expected to increase the shelf-life and maintain the biological activity of such preparations for pharmaceutical applications.

摘要

制备，干燥并在生产后零时和60天时测量释放曲线，粒度，油载，密度，湿度和水分活度，在体外制备包含干燥的马兜铃属天竺葵和Achyrocline satureioides精油的颗粒和微粒。还使用硬明胶胶囊进行了比较。测量结果表明，与颗粒相比，喷雾干燥的颗粒的含油量显着降低，并且干燥剂干燥的颗粒在60天内保持了最高的含油量。此外，明胶胶囊减少了油的损失，这有望延长货架期并保持这种制剂在制药领域的生物活性。