The importance of gem-difunctionalized ketones is represented by their broad applications across chemical boundaries over recent years. The interesting reactivities that this class of compounds possess have made them ideal building blocks to access high-value organic molecules. Furthermore, the gem-difunctionalized ketone moiety has featured in numerous bioactive molecules. For these reasons, a plethora of routes to access such significant molecules have been developed by research groups worldwide – this account looks at delineating the synthesis of gem-difunctionalized ketones from carbonyl substrates, diazo compounds, sulfur ylides and alkynyl reactants.

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Geminal α-双官能化酮的合成路线

近年来，宝石双官能化酮的重要性体现在它们跨越化学边界的广泛应用上。这类化合物所具有的有趣反应性使它们成为获取高价值有机分子的理想构件。此外，宝石双功能化的酮部分在众多生物活性分子中具有特色。出于这些原因，世界各地的研究小组开发了大量获取此类重要分子的途径——本报告着眼于描绘从羰基底物、重氮化合物、硫叶立德和炔基反应物合成宝石双官能化酮。