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Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study
Photochemistry and Photobiology ( IF 3.3 ) Pub Date : 2021-02-02 , DOI: 10.1111/php.13390
Marina Mendes Fossa Shirata 1 , Patrícia Maria Berardo Gonçalves Maia Campos 1
Affiliation  

Photoprotective formulations containing substances with antioxidant properties in combination have been used as a strategy for the improvement of photoaged skin conditions. However, there is a lack of studies evaluating the clinical efficacy of these substances in young women with signs of photoaging. Thus, the objective of the present study was to evaluate the clinical efficacy of sunscreens and cosmetic formulations containing ascorbyl tetraisopalmitate and rice peptides for the improvement of skin photoaging in young women. A double-blind, randomized placebo-controlled clinical efficacy study was conducted on 60 female subjects aged 20–30 years with skin changes related to photoaging and without photoprotective habits. The hydrolipidic layer conditions and structural and morphological characteristics of the skin were evaluated by biophysical and skin imaging techniques. The results showed that the daily use of the formulations under study improved the skin conditions by increasing skin hydration and dermis echogenicity. In addition, the application of the active substances reduced skin hyperpigmentation and increased epidermal cell renewal. In summary, the present study showed the importance of daily application of sunscreens and formulations with antioxidant properties for the prevention and attenuation of skin changes related to photoaging in young women.

中文翻译:

含有抗坏血酸四异棕榈酸酯和大米肽的防晒霜和化妆品配方用于改善皮肤光老化:一项双盲、随机安慰剂对照临床研究

含有具有抗氧化特性的物质的光保护制剂已被用作改善光老化皮肤状况的策略。然而,缺乏评估这些物质对有光老化迹象的年轻女性临床疗效的研究。因此,本研究的目的是评估含有抗坏血酸四异棕榈酸酯的防晒霜和化妆品配方的临床功效。和米肽用于改善年轻女性的皮肤光老化。对 60 名年龄在 20-30 岁的女性受试者进行了一项双盲、随机安慰剂对照的临床疗效研究,这些受试者的皮肤变化与光老化有关,但没有光保护习惯。通过生物物理和皮肤成像技术评估皮肤的水脂层状况以及皮肤的结构和形态特征。结果表明,每天使用所研究的配方可以通过增加皮肤水合作用和真皮回声来改善皮肤状况。此外,活性物质的应用减少了皮肤色素沉着过度和增加表皮细胞更新。总之,
更新日期:2021-02-02
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