Cell death is an important physiological and pathological phenomenon in multicellular animals and occurs widely in various body’s systems. In recent years, researchers have gained a deeper understanding of the mechanisms of necrosis and apoptosis in mammals. In addition, many new forms of lytic regulated cell death (RCD), such as pyroptosis, necroptosis and ferroptosis, have been discovered, thus enhancing our understanding of the molecular mechanisms of programmed cell death (PCD) and the associated signalling pathways as well as their relationship with diseases. However, our understanding of lytic RCD in fish is limited. Recently, some progress has been made regarding the induction conditions, expression of related genes and regulation of lytic RCD in fish. Furthermore, research on the roles of lytic RCD in tissue development, against pathogenic microorganism, inflammatory disease and neurological disease, has also been advanced. Understanding lytic RCD in fish will enable the regulation of its occurrence through human intervention to inhibit disease processes, improve fish health and explore possible countermeasures based on these basic theoretical studies.

中文翻译：

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水产养殖鱼中裂解调节的细胞死亡

细胞死亡是多细胞动物的一种重要生理病理现象，广泛发生于机体各系统。近年来，研究人员对哺乳动物的坏死和凋亡机制有了更深入的了解。此外，还发现了许多新形式的裂解调节细胞死亡 (RCD)，例如细胞焦亡、坏死性凋亡和铁死亡，从而增强了我们对程序性细胞死亡 (PCD) 分子机制和相关信号通路以及他们与疾病的关系。然而，我们对鱼类溶解性 RCD 的了解是有限的。最近，在鱼类的诱导条件、相关基因的表达和溶解性RCD的调控方面取得了一些进展。此外，研究溶解性 RCD 在组织发育中的作用，针对病原微生物、炎症性疾病和神经系统疾病，也取得了进展。了解鱼类中的溶解性 RCD 将能够通过人为干预来调节其发生，以抑制疾病过程，改善鱼类健康，并在这些基础理论研究的基础上探索可能的对策。