Hemp seed oil (HSO) liposomes (HSOLs) were prepared by ethanol injection-ultrasonic dispersion (EIUD). The encapsulation efficiency (EE) and oil loading ratio (OLR) were used as the response indicators to optimize the preparation conditions of the HSOLs. The average particle size (Z-Ave) of the prepared liposomes was 122 ± 1.64 nm, the polydispersity index (PDI) was 0.21 ± 0.06, the zeta potential (ZP) was -36.5 ± 0.32 mV, the encapsulation efficiency (EE) was 81.3 ± 1.62 % and the oil loading rate (LOR) was 6.13 ± 0.07 %. Transmission electron microscopy (TEM) and cryo-scanning electron microscopy (cryo-SEM) showed that the morphology of the HSOLs was round, and the cut surface was regular. The storage and oxidative stability tests of the HSOLs showed that the Z-Ave was 152 ± 1.87 nm and the polydispersity index (PDI) was 0.72 ± 0.03 after storage for 70 days under natural light at 25 °C. The zeta potential change showed no trend. The polyphenolic content in the HSOLs was 2.25 mg GAE/100 g, the DPPH clearance rate was 60.7 %, and the Δ9-tetrahydrocannabinol (Δ9-THC) content was 85.43 mg/kg.

通过乙醇注射-超声分散（EIUD）制备大麻籽油（HSO）脂质体（HSOL）。包封率（EE）和载油率（OLR）被用作响应指标，以优化HSOL的制备条件。制备的脂质体的平均粒径（Z-Ave）为122±1.64 nm，多分散指数（PDI）为0.21±0.06，ζ电位（ZP）为-36.5±0.32 mV，包封效率（EE）为81.3±1.62％，机油装载率（LOR）为6.13±0.07％。透射电子显微镜（TEM）和低温扫描电子显微镜（cryo-SEM）显示，HSOL的形态是圆形的，并且切割表面是规则的。HSOL的储存和氧化稳定性测试表明Z-Ave为152±1.87 nm，多分散指数（PDI）为0.72±0。在25°C的自然光下存放70天后的03。ζ电位变化无趋势。HSOL中的多酚含量为2.25 mg GAE / 100 g，DPPH清除率为60.7％，Δ9-四氢大麻酚（Δ9-THC）含量为85.43 mg / kg。