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Reactions of 1-benzoyl-2,4-diphenyl-2,3-dihydro-1 H -1,5-benzodiazepine with alicyclic Reformatsky reagents
Chemistry of Heterocyclic Compounds ( IF 1.5 ) Pub Date : 2021-02-03 , DOI: 10.1007/s10593-021-02872-z Elena A. Nikiforova , Dmitry P. Zverev , Maksim V. Dmitriev , Sergey N. Shurov , Nikolay F. Kirillov
中文翻译:
1-苯甲酰基-2,4-二苯基-2,3-二氢-1 H -1,5-苯并二氮杂与脂环式Reformatsky试剂的反应
更新日期:2021-02-03
Chemistry of Heterocyclic Compounds ( IF 1.5 ) Pub Date : 2021-02-03 , DOI: 10.1007/s10593-021-02872-z Elena A. Nikiforova , Dmitry P. Zverev , Maksim V. Dmitriev , Sergey N. Shurov , Nikolay F. Kirillov
The reactions of 1-benzoyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzodiazepine with methyl 1-bromocycloalkanecarboxylates and zinc, followed by hydrolysis of the reaction mixtures, resulted in the formation of spiro-δ-lactams bearing a 2-(N-benzoylamino)phenyl substituent at the nitrogen atom. The product structures were confirmed by X-ray structural analysis, and a mechanism was proposed for the product formation.
中文翻译:
1-苯甲酰基-2,4-二苯基-2,3-二氢-1 H -1,5-苯并二氮杂与脂环式Reformatsky试剂的反应
1-苯甲酰基-2,4-二苯基-2,3-二氢-1 H -1,5-苯并二氮杂与1-溴环烷羧酸甲酯和锌反应,然后水解反应混合物,形成螺环-在氮原子上带有2-(N-苯甲酰基氨基)苯基取代基的δ-内酰胺。通过X射线结构分析确认了产物结构,并提出了产物形成的机理。