Background. Myocardial fibrosis is identified as a major side effect of Diabetes Mellitus on the heart. Some biomarkers including the ratio of matrix metalloproteinases and their inhibitors in collagen synthesis and collagen degradation are clinically useful in the diagnosis and identification of myocardial fibrosis. In addition, regular aerobic exercise training is one of the major and non-pharmacological solutions for preserving and promoting cardiovascular health. Objectives. Thus, the current research aims at investigating the effect of aerobic training on levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1) in diabetic rats. Methods. 30 male Wistar rats were randomly divided into 3 groups (healthy control, diabetic control, and exercise diabetic). Diabetes was induced by intraperitoneal injection of streptozotocin at 55 mg/kg per body weight. The exercise program comprised eight weeks of running on a bar for 60 minutes at a speed of 25 m/min. Biopsy was carried out 48 h after the last exercise session, and cardiac levels of MMP-9 and TIMP-1 values were measured by the ELISA sandwich method. Results. The findings of the current research indicated that diabetes induction caused significant increase in cardiac levels of MMP-9 and significant reduction of TIMP-1 compared to the healthy group. In addition, it was revealed that the implementation of 8 weeks-aerobic exercise significantly reduced cardiac levels of MMP-9 and significantly increased TIMP-1 compared to the group without exercise. Conclusions. The execution of aerobic training in diabetic rats inhibited progressive factors of myocardial fibrosis and thus fibrosis risk in diabetic heart is

中文翻译：

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八周有氧运动对糖尿病大鼠心肌某些纤维化指标的影响

背景。心肌纤维化被认为是糖尿病对心脏的主要副作用。一些生物标志物，包括胶原蛋白合成和胶原蛋白降解中基质金属蛋白酶的比例及其抑制剂，在临床上可用于诊断和鉴定心肌纤维化。此外，定期有氧运动训练是维护和促进心血管健康的主要且非药物解决方案之一。目标。因此，本研究旨在研究有氧训练对糖尿病大鼠基质金属蛋白酶9（MMP-9）和基质金属蛋白酶1（TIMP1）组织抑制剂的影响。方法。将30只Wistar大鼠随机分为3组（健康对照组，糖尿病对照组和运动糖尿病组）。腹膜内注射链脲佐菌素每公斤体重55 mg / kg可诱发糖尿病。锻炼程序包括以25 m / min的速度在酒吧上进行60分钟的八周锻炼。在最后一次运动后48小时进行活检，并通过ELISA夹心法测量心脏MMP-9和TIMP-1值。结果。当前研究的结果表明，与健康组相比，糖尿病的诱导引起心脏MMP-9水平的显着升高和TIMP-1的显着降低。此外，还发现与没有运动的组相比，进行8周的有氧运动显着降低了心脏MMP-9水平，并显着提高了TIMP-1。结论。