Microcapillary film (MCF) is an extruded plastic film with an array of parallel microcapillaries (30–500 μm) and it has wide potential applications in bioanalytical techniques as a microfluidic platform. With different surface modification strategies, an MCF combines the advantages of its structure and modified chemical properties to realize various bioanalytical functions. In this review, we begin by introducing the manufacturing process of MCFs, common materials used to produce MCFs, surface treatment approaches of inner surfaces, and a signal detection and readout system of the MCF platform. Then, we summarize some typical applications of MCFs, particularly in protein chromatography, Escherichia coli detection for urinary tract infections, prostate-specific antigen detection for prostate cancer and multiplex immunoassays. Finally, future perspectives of MCFs in bioanalytical techniques are discussed.

中文翻译：

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微毛细管膜在生物分析技术中的应用

微毛细管膜（MCF）是具有一系列平行微毛细管（30–500μm）的挤出塑料膜，作为微流体平台在生物分析技术中具有广泛的潜在应用。通过不同的表面修饰策略，MCF结合了其结构和修饰的化学特性的优点，以实现各种生物分析功能。在本文中，我们首先介绍了MCF的制造工艺，制造MCF的常用材料，内表面的表面处理方法以及MCF平台的信号检测和读出系统。然后，我们总结了MCF的一些典型应用，尤其是在蛋白质色谱，大肠杆菌中检测尿路感染，检测前列腺癌的前列腺特异性抗原和进行多重免疫分析。最后，讨论了MCF在生物分析技术中的未来前景。