Background. The World Health Organization estimated that about 1.36 million pregnant women suffered from syphilis in 2008, and nearly 66% of adverse effects occurred in those who were not tested or treated. Syphilis infection is one of the most common maternal factors associated with stillbirth. Objective. This study aimed to determine the risk factors for stillbirth among pregnant women infected with syphilis. Methods. In this retrospective study, data on stillbirth and gestational syphilis from 2010 to 2016 were extracted from the prevention of mother-to-child transmission (PMTCT) program database in the Zhejiang province. A total of 8,724 pregnant women infected with syphilis were included. Multiple logistic regression analysis was performed to determine the degree of association between gestational syphilis and stillbirth. Results. We found that the stillbirth percentage among pregnant women infected with syphilis was 1.7% (152/8,724). Compared with live births, stillbirth was significantly associated with lower maternal age, not being married, lower gravidity, the history of syphilis, nonlatent syphilis stage, higher maternal serum titer for syphilis, inadequate treatment for syphilis, and later first antenatal care visit. In multiple logistic analysis, nonlatent syphilis (adjusted odds ratio (AOR) = 2.03; 95% CI = 1.17, 3.53) and maternal titers over 1 : 4 (AOR = 1.78; 95% CI = 1.25, 2.53) were risk factors for stillbirth, and adequate treatment was the only protective factor for stillbirth (AOR = 0.16; 95% CI = 0.10, 0.25). Conclusions. Nonlatent syphilis and maternal titers over 1 : 4 were risk factors for stillbirth, and adequate treatment was the only protective factor for stillbirth.

中文翻译：

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2010-2016年浙江省梅毒孕妇死产危险因素分析

背景。世界卫生组织估计，2008年约有136万名孕妇患有梅毒，近66%的不良反应发生在未接受检测或治疗的孕妇身上。梅毒感染是与死产相关的最常见的母体因素之一。客观的。本研究旨在确定感染梅毒的孕妇死产的危险因素。方法。本回顾性研究从浙江省预防母婴传播项目数据库中提取了2010年至2016年死产和妊娠梅毒的数据。共有 8,724 名感染梅毒的孕妇被纳入其中。进行多重逻辑回归分析以确定妊娠梅毒与死产之间的关联程度。结果。我们发现感染梅毒的孕妇的死产率为1.7%（152/8,724）。与活产相比，死产与较低的母亲年龄、未婚、较低的妊娠率、梅毒病史、非潜伏梅毒阶段、母亲梅毒血清滴度较高、梅毒治疗不充分以及首次产前检查较晚显着相关。在多重 Logistic 分析中，非潜伏梅毒（调整后优势比 (AOR) = 2.03；95% CI = 1.17, 3.53）和母体滴度超过 1:4（AOR = 1.78；95% CI = 1.25, 2.53）是死产的危险因素，充分的治疗是死产的唯一保护因素（AOR = 0.16；95% CI = 0.10，0.25）。结论。非潜伏梅毒和母体滴度超过1：4是死产的危险因素，充分的治疗是死产的唯一保护因素。