SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in several cellular and developmental processes. Gain-of-function germ line mutations of SHOC2 drive the RASopathy Noonan-like syndrome, and SHOC2 mediates adaptive resistance to mitogen-activated protein kinase (MAPK) inhibitors. Similar to many scaffolding proteins, SHOC2 facilitates signal transduction by enabling proximal protein interactions and regulating the subcellular localization of its binding partners. Here, we review the structural features of SHOC2 that mediate its known functions, discuss these elements in the context of various binding partners and signaling pathways, and highlight areas of SHOC2 biology where a consensus view has not yet emerged.

中文翻译：

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富含亮氨酸的重复蛋白提供 SHOC2 RAS 电路：结构功能视角

SHOC2 是一种典型的富含亮氨酸的重复蛋白，可促进下游受体酪氨酸激酶 (RTK)/RAS 信号传导，并在多个细胞和发育过程中发挥重要作用。SHOC2 的功能获得性生殖系突变驱动 RAS 病 Noonan 样综合征，而 SHOC2 介导对丝裂原活化蛋白激酶 (MAPK) 抑制剂的适应性抵抗。与许多支架蛋白类似，SHOC2 通过启用近端蛋白质相互作用和调节其结合伙伴的亚细胞定位来促进信号转导。在这里，我们回顾了 SHOC2 介导其已知功能的结构特征，在各种结合伙伴和信号通路的背景下讨论这些元素，并强调尚未出现共识观点的 SHOC2 生物学领域。