Bacterial phytopathogens represent a significant threat to many economically important crops. Current control measures often inflict harm on the environment and may ultimately impact on human health through the spread of antibiotic resistance. Antimicrobial proteins such as bacteriocins have been suggested as the next generation of disease control agents since they are able to specifically target the pathogen of interest with minimal impact on the wider microbial community and environment. However, substantial gaps in knowledge with regards to the efficacy and application of bacteriocins to combat phytopathogenic bacteria remain. Here we highlight the immediate challenges the community must address to ensure maximum exploitation of antimicrobial proteins in the field. © 2021 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

中文翻译：

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使用蛋白质抗生素控制病原体的挑战

细菌性植物病原体对许多具有重要经济意义的作物构成重大威胁。当前的控制措施通常会对环境造成危害，并可能最终通过抗生素耐药性的传播影响人类健康。抗菌蛋白（例如细菌素）已被建议作为下一代疾病控制剂，因为它们能够专门针对感兴趣的病原体，而对更广泛的微生物群落和环境的影响最小。然而，关于细菌素对抗植物病原菌的功效和应用方面的知识仍然存在巨大差距。在这里，我们强调了社区必须解决的紧迫挑战，以确保在该领域最大限度地利用抗菌蛋白。© 2021 作者。害虫管理科学 由 John Wiley & Sons Ltd 代表化学工业协会出版。