We have examined the mixed micellar behavior of {amphiphilic drug; chlorpromazine hydrochloride (CPZ) + cationic surfactant; cetyltrimethylammonium bromide (CTAB)} at varying mole fractions of CPZ (α_CPZ = 0.2, 0.4, 0.6, and 0.8) in (0.1, 0.3, and 0.5) mol kg⁻¹ glycine_(aq) solutions at 298.15, 308.15, and 318.15 K, by using conductometric, volumetric, isentropic compressibility, UV–visible absorbance, fluorescence, and dynamic light scattering (DLS) techniques. The critical micelle concentration (CMC) values obtained from above measurements have been utilized to calculate the thermodynamic parameters (ΔG^°_m, ΔH^°_m, and ΔS^°_m) and degree of ionization (α) at studied temperatures and concentrations. The partial specific volume (φ_v), partial specific isentropic compression (φ_κ), and isentropic compressibility (κ_s) have been calculated from the experimental density and speed of sound measurements and the results have been used to elucidate different interactions occurring in these systems. These results are further supported by UV–visible absorbance and fluorescence spectroscopic studies. The hydrodynamic diameters (D_h) of the mixed micellar system have been measured from the DLS studies. Thermodynamic and spectroscopic studies depict the dominance of hydrophobic/hydrophilic‐hydrophobic interactions between the alkyl (R = C₁₆H₃₃) chain of CTAB or hydrophobic tricyclic scaffolding of CPZ/Br⁻/N⁺‐CH₃ group of CTAB or hydrophilic group i.e., tertiary amine portion of CPZ with hydrophobic group of glycine.

中文翻译：

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（盐酸氯丙嗪+十六烷基三甲基溴化铵）在甘氨酸水溶液中的混合胶束行为

我们已经检查了两亲药物的混合胶束行为。盐酸氯丙嗪（CPZ）+阳离子表面活性剂；十六烷基三甲基铵（CTAB）}在CPZ的不同摩尔分数（α _CPZ在（0.1，0.3，0.5）摩尔千克= 0.2，0.4，0.6和0.8）^-1甘氨酸_{（水溶液）}溶液在298.15，308.15，318.15和通过使用电导，体积，等熵可压缩性，紫外可见吸收率，荧光和动态光散射（DLS）技术来测定K。通过上述测量获得的临界胶束浓度（CMC）值已用于计算热力学参数（ΔG ^° _m，ΔH ^° _m和ΔS ^° _m）和在研究温度和浓度下的电离度（α）。的部分比容（φ _v），部分特定等熵压缩（φ _κ）和等熵压缩（κ_小号）已经从实验密度和声音测量的速度来计算，其结果已被用于阐明发生在这些不同的相互作用系统。紫外可见吸收和荧光光谱研究进一步支持了这些结果。流体力学直径（D _h混合胶束系统的）已通过DLS研究进行了测量。热力学和光谱研究描述了烷基之间的疏水性/亲水性-疏水性相互作用（R = C的主导地位₁₆ ħ ₃₃）CTAB的链或疏水三环CPZ脚手架/ Br中^- / N ⁺ -CH ₃基团或CTAB亲水性基团的，即，CPZ的叔胺部分具有甘氨酸的疏水基团。