A novel and efficient method for the nucleophilic α‐hydrolysis of α‐halohydroxamates under metal‐free conditions was achieved. The simple and readily available dimethyl sulfoxide (DMSO) was used as a catalyst, while water served as the nucleophile and oxygen source. This method was successfully employed in the synthesis of secondary α‐hydroxy‐α‐alkyl and α‐hydroxy‐α‐arylhydroxamates as well as tertiary α‐hydroxy‐α‐dialkylhydroxamates.

中文翻译：

---

在温和条件下高效DMSO促进α-卤代异羟肟酸酯的α-水解

实现了一种新颖且有效的无金属条件下α-卤代异羟肟酸酯亲核α-水解的方法。简单易用的二甲基亚砜（DMSO）用作催化剂，而水用作亲核试剂和氧气源。该方法成功地用于合成仲α-羟基-α-烷基和α-羟基-α-芳基异羟肟酸酯以及叔α-羟基-α-二烷基异羟肟酸酯。