Fetal programming was characterized a few decades ago, explaining the correlation of physiological phenotypes of offspring exposed to early‐life stress. High acute or chronic prenatal stress can overwhelm the enzymatic placental barrier, inducing transcriptional changes in the fetus that can result in different adverse behavioral and physiological phenotypes. The current study investigates the impact of exposure to the synthetic glucocorticoid, dexamethasone, during late gestation on behavioral outcomes.

中文翻译：

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Wistar Kyoto大鼠的妊娠晚期妊娠地塞米松暴露和胎儿程序异常行为

胎儿编程的特点是几十年前，它解释了暴露于生命早期压力的后代的生理表型的相关性。较高的急性或慢性产前应激会压倒酶促胎盘屏障，导致胎儿的转录变化，从而导致不同的不良行为和生理表型。当前的研究调查了妊娠后期暴露于合成糖皮质激素地塞米松对行为结局的影响。